Author's Note: I acknowledge that the following is controversial. This article was written early in 1998. Since then my views have moderated and I feel there are many patients for whom methadone is going to be vital. Its ability to enforce compliance by addiction, and its ability to ameliorate anguish in people who are not yet ready to do any psychotherapy or recovery, means it will have a role for the majority of addicts. Those on the RACGP work group setting up a mechanism for approval for GPs to become TGA 19(5) approved naltrexone prescribers, all feel it will be necessary for easy access to go back to methadone for patients who become unstable on naltrexone.
Interested GPs are recommended to buy the excellent summary of current knowledge in NDARC Monograph 34 on the role of naltrexone in heroin addiction. This costs $10 including postage and may be ordered from the National Drug And Alcohol Research Centre, University of NSW, NSW 2052.
Lismore seems to have a critical mass of hopeful families, community support, and willing GPs to see naltrexone offered in a way that might succeed. I believe that Lismore has the potential to be a centre of excellence in the care of opiate dependence with the assistance of naltrexone, because of the wonderful model you have in palliative care - combining good medical science with a caring community with care focused on family.
On the Gold Coast we are trying to get a network of community support and volunteers to keep in touch with families and ex-addicts, similar to the AMPRF program style that George Oneil has. (Ed note: AMPRF stands for Australian Medical Procedures Research Foundation, a non-profit organisation associated with Perth-based Dr George Oneil and his team approach to the recovery of heroin addicted patients.) Ron Allen worked with the Perth program and has come across to assist in getting a caring network working.
My oldest friend in Perth is George Oneil, and I visited his 'naltrexone church program' as he calls it, on a trip to see my family back in September. Before that I had felt that methadone was the best bet, and had been most grateful for all that I learned from Dr Andrew Byrne's excellent books.
On my return I saw a 19 year old patient who said - I stopped using methadone because I was still using heroin, so I thought I might as well stick with one thing, then I wiped out my car with my two year old on board, and decided to just dry out at home, and I haven't used for 10 days and I am dreaming about heroin and craving and can't stop thinking about it - can you help me? So I faxed Dr Allan Black in TGA and described her story and he approved naltrexone. She tolerated narcan and took a tablet, and immediately stopped craving heroin and stopped dreaming about it! She has had one slip for a few days and is OK again now.
Since then I have treated about 50 patients. This includes a couple of Israel UROD (ultra rapid opiate detoxification patients who fell off the bus, and people with habits ranging from $25 to $1000 daily. I have learned from treating them (backed up by studies on Cochrane Database) that:
- There is no point in using NTX unless the patient brings a personal carer (preferably family), and there is a counselling process for ex-addict as well as family. Pre detox psychotherapy, particularly relating to trauma processing (using EMDR if a trained person is available), is very important.
- It is probably unethical to make people detox for seven days before introducing NTX. A couple of studies in Cochrane show that (a) success in achieving detox, and (b) long term benefit as measured by compliance with groups and counselling at six months, is much greater in those whose detox was accelerated with tiny doses of naltrexone.
- Teaching people to detox (using clonidine, +/- melleril, temazepam, quinine, loperamide) using an eyedropper with 50mg naltrexone dissolved in 5ml of water, using 1 drop (=3D0.4mg) every hour (having breaks when necessary), gives them a simple way of restarting naltrexone without having to wait for an ICU bed in a teaching hospital or Israel, if they happen to have a 'fall' later.
- UROD, and even ROD in an institution, disempowers families. That doesn't make sense, when we know long term outcomes depend on family engagement. Family based, medically assisted, naltrexone micro-dose accelarated detox seems to get strong approval from participants who have been through all the other ways before.
- Mental craving will often disappear within 12 hours on the naltrexone micro-dosing detox. Physical withdrawal scores usually settle within 48 hours. Perhaps it should be called AAOD - accelarated ambulatory opiate detoxification.
Dr Hugh Nelson, Gold Coast.
Email: hugh.nelson@ausinfo.com.au
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