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Rosacea

Rosacea

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Incidence


The most likely diagnosis of a chronically red face is rosacea. Erythema occurs in a "cruciate" distribution affecting the cheeks, forehead, nose, chin and occasionally the balding male scalp. It is usually bilaterally symmetrical and most common in females of Celtic origin.

There are two peaks in age of onset - 20s to 30s and the 40s to 50s. Rosacea starts with episodic flushing which gradually gives way to a fixed erythema. Persistent telangiectasia develops in the affected area and acute inflammatory episodes may occur with the formation of non tender papules and pustules. The role of the Demadex follicularum mite in the pathogenesis of rosacea is still
unclear but a local delayed hypersensitivity response to Demadex antigens may be partly responsible for the inflammatory component.

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Precipitants


Precipitating stimuli for rosacea include heat, UV light, spicy foods, stress, exercise, alcohol and hot tea or coffee.

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Differential Diagnosis


The differential diagnosis includes:


  • acne vulgaris - which may coexist with rosacea, but usually has comedomes and tender papules

  • telangiectasia due to chronic sun exposure

  • seborrhoeic dermatitis - may be unresponsive to antibiotics affecting the nasolabeal folds, alar groove, eyebrows, eyelids with erythema and a greasy scale

  • perioral dermatitis - characterised by small red papules sparing the area adjacent to the vermillion border without background erythema and usually due to fluorinated steroid creams

  • SLE - malar butterfly rash, but rarely facial flushing or inflammatory episodes

  • and carcinoid syndrome - no pustules but has spontaneous flushing associated with diarrhoea.


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Management


Management involves identifying and avoiding any precipitating factors. All sources of heat, such as excessively hot baths or showers, saunas, direct radiant heat and hot beverages should be avoided. Exposure to ultraviolet light should be limited and sunscreen used. Intake of spicy food and alcohol should be reduced or eliminated. An extractor fan in the kitchen to minimise the heat
from steam while cooking may be worthwhile. Cotton sheets and as few blankets as possible will minimise overheating at night and excessive room heating during winter should be avoided.

First line treatments are topical antibiotics, eg. metronidazole 0.75% gel twice daily. Alternatively clindamycin 2% lotion may be used. If the alcohol base is too drying, it can be reformulated in Cetaphil lotion. If there is no improvement after eight weeks, systemic antibiotics should be started eg. Tetracycline 250mg QID, minocycline or doxycycline 50mg BD. If these agents cause nausea or photosensitivity, erythromycin 500mg BD or metronidazole 200mg may be used. Treatment time is at least eight weeks and some patients require long term maintenance therapy. Severe recalcitrant rosacea may require isotretinoin. Facial erythema can be difficult to treat, may be unresponsive to antibiotics, but persistent telangiectasia can be helped by vascular laser therapy.

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Complications


Rhinophyma, a bulbous swelling of the nose due to sebaceous gland hyperplasia is the commonest complication of rosacea. This can be treated surgically by paring or CO2 laser therapy. Up to 50% of patients have inflammatory ocular complications such as conjunctivitis or blepharitis. Rosacea keratitis needs early recognition and treatment with steroid eyedrops to prevent corneal
scarring.

Tip


Avoid potent steroids in rosacea, and only use hydrocortisone for short periods.

Dr Graham Ellis practises in the Goonellebah Medical Centre, Lismore, NSW, Australia.

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